Complexities of Viral Mutation Rates
نویسندگان
چکیده
منابع مشابه
Viral mutation rates.
Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c)...
متن کاملViral evolution under the pressure of an adaptive immune system - optimal mutation rates for viral escape
Based on a recent model of evolving viruses competing with an adapting immune system [1], we study the conditions under which a viral quasispecies can maximize its growth rate. The range of mutation rates that allows viruses to thrive is limited from above due to genomic information deterioration, and from below by insufficient sequence diversity, which leads to a quick eradication of the virus...
متن کاملRates of spontaneous mutation.
Rates of spontaneous mutation per genome as measured in the laboratory are remarkably similar within broad groups of organisms but differ strikingly among groups. Mutation rates in RNA viruses, whose genomes contain ca. 10(4) bases, are roughly 1 per genome per replication for lytic viruses and roughly 0.1 per genome per replication for retroviruses and a retrotransposon. Mutation rates in micr...
متن کاملReply to "Complexities of Estimating Evolutionary Rates in Viruses".
We appreciate the valuable feedback offered by Dr. Holmes (1) and would like to follow up on some of the important points. The goal of our study was to evaluate the feasibility of identifying areas in which to focus surveillance efforts to better detect the emergence of new influenza strains and subtypes, using the currently available data, both for potential targeting of future surveillance an...
متن کاملViral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.
Many viruses, particularly RNA viruses, mutate at a very high rate per genome per replication. One possible explanation is that high mutation rates are selected to meet the challenge of fluctuating environments, including the host immune response. Alternatively, recent studies argue that viruses evolve under a trade-off between replication speed and fidelity such that fast replication is select...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2018
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01031-17